AGT and ischemia: In the absence of oxygen (ischemia), NADH accumulates (highly reduced) because complex IV is blocked; in the current study, as it has been shown previously (48, 82), NADH increased (reduced redox state) during ischemia, but to the same levels in the TERT−/− and WT rats; on reperfusion, the mitochondria were relatively more reduced in the WT compared to the TERT−/− in the Ang II untreated rats, which would suggest better availability of reducing equivalents (NADH/FADH2) for OXPHOS to provide ATP for better recovery of LVP and RPP in the WT.