Although the TERT−/− and the WT counterparts displayed similar cardiac function and structure as shown by echocardiography and ex vivo pre-ischemia cardiac analysis, basal LVP (Table 1) in the TERT−/− I/R hearts from the Ang II treated group exhibited reduced Dev-LVP and RPP, and higher diastolic LVP. The gene discussed is TERT; the disease is ischemia.