In a strategy to increase eIF2α-P, GADD34 inhibitors (salubrinal, guanabenz, sephin 1) were tested, showing beneficial effects in mouse models of prion disease (Das et al., 2015), PD (Sun et al., 2018), and ALS (Tsaytler et al., 2011), but accelerated disease progression in another ALS study (Vieira et al., 2015). Here, PPP1R15A is linked to amyotrophic lateral sclerosis.