We thus further analyzed the data from TCGA and showed that HPSE is positively correlated with the expression of MMP1 in colon cancer (r = 0.3476, p < 0.0001) and rectal cancer (r = 0.3428, p < 0.0001) (Figures 7A,B), but not MMP7, MMP10, and MMP13 (Figure S1). The gene discussed is MMP1; the disease is malignant colon neoplasm.