Notably, these DEGs are highly enriched in pathway involved in ECM remodeling, including “collagen degradation,” “activation of matrix metalloproteinases,” “extracellular matrix organization” and “degradation of the extracellular matrix,” further suggesting the importance of HPSE in CRC invasion and metastasis (Figure 6A). The gene discussed is HPSE; the disease is colorectal carcinoma.