CSF1 and neoplasm: However, RT also inhibits antitumor immunity by facilitating the development of immune suppressive cells, such as T regulatory cells (Tregs) (31), tolerogenic and immune suppressive dendritic cells (DC) (32), tumor-associated macrophages (TAMS) (33), tumor-associated neutrophils (TANs) (34), and MDSC (24), via a series of soluble molecules such as TGFβ (35), adenosine (36), VEGFA (37), CSF1 (24), and CCL2 (38).