TNF and neoplasm: These included marked activation (indicated by activation z-scores) of tumor-promoting mediators such as IL-1β, IFNγ, TNF, NF-κB, and RELA, transcription regulators of the antioxidant pathway such as FOXO3 and NFE2L2 (otherwise known as NRF2), as well as growth promoting kinases including glycogen synthase kinase 3 beta (GSK3β) (all z-scores > 2.0 and P < 0.0001) (Table S7).