Conversely, we found that Wnt7a, a component of the Wnt/β-catenin pathway (46) and the loss of which was previously reported to promote an undifferentiated tumor-protective phenotype in NSCLC (24), was markedly suppressed in the Gprc5a−/−Kras-mutant LUAD CSCs relative to parental cells. The gene discussed is WNT7A; the disease is neoplasm.