RNA-Seq analysis had revealed the up-regulation of various aldehyde dehydrogenase isozymes (Table S5), the most notable of which were Aldh1a1, Aldh1a3, and Aldh3a1, known to be important for maintenance and self-renewal of stem cells and that were reported to be widely over-expressed in CSCs from various tumor types (23). The gene discussed is ALDH1A1; the disease is neoplasm.