NOTCH1 and acute lymphoblastic leukemia: Recently, Choi and colleagues demonstrated that Notch1 and Notch3 drive a common oncogenic transcriptional program in T-ALL and that most of the functional Notch3 binding sites in TALL-1 cells, similarly to what was observed previously by Aster group for Notch1 in CUTLL1 cells (15), are located in enhancer regions associated with dynamic H3K27ac modulation (10).