NOTCH1 and acute lymphoblastic leukemia: These last findings further indicate c-Myc as a prominent mediator of Notch oncogenic function that is consistent with the essential role of c-Myc in Notch1-driven leukemia (5, 44, 45) and with its property to rescue T-ALL cells from the anti-growth effects of Notch1 inhibition by GSI treatment (6, 44).