Recently, Choi and colleagues demonstrated that Notch1 and Notch3 drive a common oncogenic transcriptional program in T-ALL and that most of the functional Notch3 binding sites in TALL-1 cells, similarly to what was observed previously by Aster group for Notch1 in CUTLL1 cells (15), are located in enhancer regions associated with dynamic H3K27ac modulation (10). Here, NOTCH3 is linked to acute lymphoblastic leukemia.