CACNA2D3 and central nervous system cancer: The human CACNA2D3 gene is located on the short arm of chromosome 3 at position 3p21.1, a common region of allelic deletion, and has been found to possess a potential tumor suppressor function in multiple tumor types, including gastric cancer (11–13), nasopharyngeal cancer (14), breast cancer (15), renal cell cancer neuroblastoma (16), lung cancer (17), and glioma (18).