Several other molecular pathologies were found in CLL, such as the overexpression of the unmutated immunoglobulin heavy chain variable region (IGHV) genes, zeta-chain-associated protein kinase 70 (ZAP-70), CD38 proteins, and mutations in the NOTCH1, splicing factor 3b subunit 1 (SF3B1), and baculoviral IAP repeat-containing 3 (BIRC3) genes. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.