On the other hand, Shiraishi et al. have reported that HO-1 overexpression could be related to a reduction of kidney damage, due to HO-1 degrades heme moiety, acting as scavenging peroxy radical and inhibiting lipid peroxidation [30, 62], which could explain the low lipid peroxidation ratio in the ISS group at day 4 post-AKI, and an augment of this ratio in this group at day 8 post-AKI, which is also related with HO-1 gene overexpression in the ISS group at day 4 post-AKI. This evidence concerns the gene HMOX1 and acute kidney injury.