The top modular genes, TOP2A, CDC20, PRC1, CCNB2, and NUSAP1, were highly associated with HCC onset and development; high expression of TOP2A, CDC20, or CCNB2 was correlated with poor survival time in TCGA liver cancer patients, implying their potential as biopsy-based prognostic markers. This evidence concerns the gene TOP2A and hepatocellular carcinoma.