Among the nine-lncRNAs, lncRNA ATXN8OS participate in spinocerebellar ataxia by affecting the localization and activity of splicing factors and mutations in the ATXN8OS are associated with the amyotrophic lateral sclerosis (Moseley et al., 2006; Hirano et al., 2018). Here, ATXN8OS is linked to amyotrophic lateral sclerosis.