Also, the mutation effects on TF binding at the promoter of two important FL genes (BCL6 and BCL2) (Pasqualucci et al., 2014) were recovered: for example, regulatory activities of two TFs (FOXD2 and FOXD3) on BCL6 and BCL2 were confirmed previously by knockdown experiments in SUDHL4 lymphoma cell (Batmanov et al., 2017). Here, FOXD3 is linked to lymphoma.