APC and cancer: There are clear examples with germline mutations in genes like adenomatous polyposis coli (APC), cadherin 1 (CDH1), BRCA1, von Hippel-Lindau tumor suppressor (VHL), and ataxia telangiectasia mutated (ATM) which are causative for the development of cancer in specific types of tissue (Schneider et al., 2017).