C3aR in neutrophils stimulates neutrophils extracellular traps (NETs) (90), extracellular structures composed of chromatin and degrading enzymes (myeloperoxidase, cathepsin G, and elastase) that contribute to form a three-dimensional scaffold that supports fibrin deposition and thrombus stabilization and entraps platelets, erythrocytes and tumor cells, driving a protumorogenic state (91). Here, C3AR1 is linked to neoplasm.