HK1 and primary biliary cholangitis: In a cohort of 366 patients with PBC, ~40 and 45% of 277 AMA-positive patients were positive for anti-KLHL12 or anti-HK-1 antibodies respectively, while in 89 AMA-negative patients 53 and 42% were positive for anti-KLHL12 or anti-HK-1 antibodies, respectively.