The overexpression and polymorphisms of HLA-G, a non-classical HLA class I (Ib) molecule with the capacity of suppressing the cytotoxic activity of T and NK cells, were found to be associated with HPV infection and the development of cervical cancer (35), whereas no correlation between HPV and HLA-G was observed in oral squamous cell carcinoma (OSCC) (36). This evidence concerns the gene HLA-G and oral cavity squamous cell carcinoma.