In DM patients who had anti-CADM-140/MDA5 autoantibodies and rapidly progressive interstitial lung disease, the mean titer of anti-CADM-140/MDA5 of anti-CADM-140/MDA5 significantly decreased in the responder group compared to non-responders (P = 0.033) (57). The gene discussed is IFIH1; the disease is dermatomyositis.