IL-1α and IL-1β cytokines stimulate the release of chemotactic cytokines such as IL-8, either directly or in synergy with TNF-α (28, 29) and are involved in the pathologies of several skin diseases including psoriasis, cutaneous lupus erythematosus, atopic dermatitis, and autoimmune blistering diseases (11, 30). This evidence concerns the gene CXCL8 and atopic eczema.