IL-1α and IL-1β cytokines stimulate the release of chemotactic cytokines such as IL-8, either directly or in synergy with TNF-α (28, 29) and are involved in the pathologies of several skin diseases including psoriasis, cutaneous lupus erythematosus, atopic dermatitis, and autoimmune blistering diseases (11, 30). The gene discussed is IL1B; the disease is cutaneous lupus erythematosus.