Here, we evaluated the importance of HIV-1 env proviral diversity as a possible prognostic marker of immunologic and/or virologic progression in our EC cohort by analyzing the plasma viremia, total cell-associated HIV DNA levels, CD4+ T cells dynamics, CD8+ T cell activation and inflammatory biomarkers over infection course in EC harboring proviral quasispecies with low (ECLD = 4) and high (ECHD = 6) env diversity. The gene discussed is CD4; the disease is infection.