SLC16A2 and hyperthyroidism: Strikingly, the effects of MCT8/SLC16A2 mutations, which in human cause severe brain hypothyroidism with concomitant hyperthyroidism in circulation and peripheral organs, known as Allan-Herndon-Dudley syndrome (AHDS), characterized by severe intellectual and motor disability (257–259), are not fully recapitulated by mice, especially with regard to the neurological phenotype (91, 260–262).