Interestingly, Rhes functions in G-protein coupled receptor signaling as well as in PI3K/Akt/mTOR pathways (253, 254) to modulate synaptic transmission (255), and Rhes KO animals have deficits in striatum-controlled behaviors (256), providing a potential functional link between hypothyroidism and resulting motor and affect dysfunctions. The gene discussed is RASD2; the disease is hypothyroidism.