Yvan-Charvet et al. reported that Ldlr−/− mice on an HFHC diet that were transplanted with Abca1−/−Abcg1−/− bone marrow cells showed accelerated atherosclerosis and extensive infiltration of myocardium and spleen with macrophage foam cells as compared to transplantation with wild-type bone marrow cells (31). Here, LDLR is linked to atherosclerosis.