Yvan-Charvet et al. reported that HFHC diet administered Ldlr+/− mice transplanted with cellular cholesterol efflux pathway-deficient Abca1−/−Abcg1−/− bone marrow cells displayed a myeloproliferative neoplasm (MPN)-like phenotype, and expression of an APOA1 transgene that elevates HDL levels suppressed this phenotype (32). The gene discussed is LDLR; the disease is myeloproliferative neoplasm.