APOB and amyotrophic lateral sclerosis: A large 20-year study in Sweden showed lower levels of serum glucose and higher levels of low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and apoB/apoA-I ratio during the 20 years before diagnosis, and increasing levels of LDL-C, high-density lipoprotein cholesterol (HDL-C), apoB and apoA-I in the 10 years before diagnosis, in 623 ALS patients.