Because determining the pathogenicity of VUS is crucial to interpreting their clinical significance (3), we aimed to improve the classification of SCN1A missense variants identified in patients with DS by combining and modifying the criteria for classifying variants proposed by the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) (3). Here, SCN1A is linked to Dravet syndrome.