Meantime, plasma triglycerides, cholesterols and free fatty acids were elevated, with severe liver fat accumulation, however, surprisingly, this kind of mouse model was protected from diet- or genetically-induced obesity, probably because the adipocyte differentiation was impaired in the absence of FXR (Sinal et al., 2000; Cariou et al., 2006). Here, NR1H4 is linked to obesity due to melanocortin 4 receptor deficiency.