On the one hand, HUWE1 is able to enhance tumor cell proliferation by K63-poly ubiquitination and activation of the transcription regulator MYC (Adhikary et al., 2005), on the other hand, depletion (Inoue et al., 2013) or mutation (Myant et al., 2017) of HUWE1 lead to increased MYC levels, thereby promoting skin and colon tumorigenesis. Here, MYC is linked to neoplasm.