APOE and Hypercholesterolemia: Apolipoproteins E and A1 also appear to promote the regression of atherosclerosis in diet-induced hypercholesterolemia and advanced aortic atherosclerotic lesions (Raffai et al., 2005), and appear to be critical in the regulation of lipid profiles (prevention of hyperlipidemia) and subsequent inflammation-induced atherosclerosis (Centa et al., 2018; Favari et al., 2018).