Clusterin protects cardiomyocytes from apoptosis through the Akt/GSK-3β signaling pathway (Jun et al., 2011), and protects the heart from damage caused by myocardial infarction (Foglio et al., 2015), transplant (Li et al., 2011), or myocarditis (McLaughlin et al., 2000) (reviewed in: Pereira et al., 2018). This evidence concerns the gene CLU and myocardial infarction.