It is thought that apoptosis of cardiomyocytes is one of the main age-related contributors to development of heart disease (Kumar et al., 2002; Goldspink et al., 2003), thus the increase in abundances of three clusterin proteoforms following acute-exercise may be responsible for the lower levels of heart disease seen in individuals who are more active (Buchner, 2009). Here, CLU is linked to heart disorder.