TTR and amyloidosis: ATTR can arise either due to senescent event associated with the wild-type TTR gene leading to wild-type amyloidosis (formerly known as senile systemic amyloidosis), or hereditary ATTR due to mutations in the TTR gene, leading to either familial amyloid polyneuropathy (ATTR-FAP), familial amyloid cardiomyopathy (ATTR-FAC), or a rare form of oculoleptomeningeal amyloidosis (OLMA) (Ando et al., 2005; Rapezzi et al., 2010; Leung et al., 2013; Mathieu et al., 2018).