Multiple reports have suggested a role for aberrant CXCL1/CXCR2 signaling in adult CNS injury including stroke, traumatic brain injury (TBI), temporal lobe epilepsy, (Xu et al., 2017) neuropathic nociception, (Abbadie et al., 2009; Yang et al., 2016) central sensitization, (Zhang et al., 2013; Manjavachi et al., 2014) and mechanical hypersensitivity (Chen et al., 2018). Here, CXCL1 is linked to stroke disorder.