In glioma cells, several key regulatory elements of cell cycle and apoptosis alter the expression of cyclin-dependent kinases such as Bcl-2 protein family, p53 protein, inhibitor of apoptosis proteins (IAPs) or receptor tyrosine kinases like the epidermal growth factor receptor (EGFR) and their down-stream signaling cascade. This evidence concerns the gene TP53 and central nervous system cancer.