The stepwise binary regression analysis performed on demographic, clinical and laboratory data collected at the start of treatment did not identify any variable capable to anticipate the lack of ANA efficacy; conversely, the number of swollen joints at baseline was the only variable capable to predict secondary inefficacy, while the presence of the typical salmon-like skin rash represented the sole variable associated with the lack of ANA withdrawal owing to sustained clinical remission. Here, BTG3 is linked to Skin rash.