In this regard, a possible role of the innate immune system of the skin has been suggested in maintaining the degree of systemic inflammation in AOSD (Ruscitti et al., 2016a), while tissue IL-1 levels and other IL-1 family members have proved to be expressed largely in the skin of AOSD patients (Chen et al., 2004; Ruscitti et al., 2016a; Han et al., 2017). The gene discussed is IL1B; the disease is adult-onset Still disease.