LXA4 enhances CFTR-independent Cl− efflux from CF bronchial epithelial cells and inhibits Na+ reabsorption, thus restoring the airway surface hydration (ASL) that is important for mucociliary clearance (Verriere et al., 2012; Al-Alawi et al., 2014; Higgins et al., 2016; Ringholz et al., 2018). This evidence concerns the gene CFTR and cystic fibrosis.