NFKB1 and cystic fibrosis: Increased release inflammatory cytokines and chemokines through NF-κB and intracellular stress signals (e.g., Ca2+) have been largely documented in AEC isolated from CF patients (Weber et al., 2001; Perez et al., 2006; Hybiske et al., 2007) and can contribute to the non-resolving feature of inflammation in CF (Roesch et al., 2018).