Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of intracellular tau in neurofibrillary tangles and neuropil threads, and the deposition of insoluble extracellular β-amyloid (Aβ) plaques associated with dystrophic neurites and synapse loss (Braak and Braak, 1991; Thal et al., 2002). The gene discussed is MAPT; the disease is Alzheimer disease.