Stroke-induced inflammation and the activation of proinflammatory mediators have been the focus of recent research into the mechanisms of stroke-induced brain damage (Chen et al., 2017; Stonesifer et al., 2017), and high-mobility group box 1 protein (HMGB1), a typical damage-associated protein, has gained particular interest (Choi et al., 2018; Shichita et al., 2017). This evidence concerns the gene PROS1 and Stroke.