In addition, a recent study have shown that oxygenized low density lipoprotein (OxLDL), a risk factor of stroke, stimulates HMGB-1 secretion in macrophages resulted from oxidative stress, then HMGB1 can contribute to macrophage-derived foam cells formation via ERS/CHOP pathway (Wu et al., 2018). The gene discussed is DDIT3; the disease is stroke disorder.