Combining these data with the previously reported anxiety- and depressive-like behaviors of NCS-1−/− mice (De Rezende et al., 2014; Ng et al., 2016) implicates NCS-1 in a relationship of diabetes type 2 and depression, frequently observed with human patients (Nouwen et al., 2010; Renn et al., 2011; Haljas et al., 2018). Here, NCS1 is linked to major depressive disorder.