An imbalance in Cer level and Cer species is a common feature in PD mouse models and PD post mortem brains (Abbott et al., 2014; Murphy et al., 2014; Ferrazza et al., 2016) and has been hypothesized as an upstream event responsible for neuronal degeneration through various pathological processes including apoptosis, autophagy, inflammation, and phagocytosis. This evidence concerns the gene CBLN1 and Parkinson disease.