MAPT and glaucoma: Interestingly, previous study have reported that the cytoskeletal proteins, such as tau, neurofilament, calpain-mediated spectrin breakdown product, β-tubulin, and Aβ were changed expressions not only in retina and optic nerve but also throughout the entire retinal projection (primary projection target in mouse, the superior colliculus) in glaucoma mouse model (Wilson et al., 2016).