IL-1β is considered a participant in the initiation of the autoimmune response of human neuropathies and the animal model EAN (Bettelli et al., 2008), IL-6 is believed to amplify local inflammation and be crucial for the EAN progression (Zhang et al., 2008b), iNOS produces pro-inflammatory NO (Abramson et al., 2001), and iNOS up-regulation in EAN was proved to contribute to the demyelination and even axonal damage in PNS (Conti et al., 2004). This evidence concerns the gene NOS2 and neuropathy.