Univariable and multivariable Cox regression analyses revealed that negative LGR5 expression was a statistically significant risk factor for peritoneal recurrence (HR: 2.79, 95% CI: 1.37–5.67, p = 0.005) as well as poor differentiation (HR: 3.90, 95% CI: 1.15–13.28, p = 0.029), positive lymph node metastasis (HR: 3.37, 95% CI: 1.44–7.86, p = 0.005), preoperative CEA > 5 ng/mL (HR: 2.25, 95% CI: 1.08–4.67, p = 0.031) and anastomotic leakage (HR: 8.57, 95% CI 1.81–40.68, p = 0.007) (Table 2). The gene discussed is LGR5; the disease is metastatic malignant neoplasm in the lymph nodes.