LGR5 was reported to alter the actin cytoskeleton structure and increased cell–cell adhesion by coupling to the intracellular scaffold signalling protein.28,31 The study suggested that the major function of LGR5 may be to promote strong intracellular adhesion among stem cells and to retain them within the crypt base to maintain homoeostasis in the intestinal epithelium.31 Weakened adhesion between cancer cells may facilitate the formation of intraperitoneal-free cancer cells, which may lead to peritoneal metastasis. Here, LGR5 is linked to cancer.