Among the factors, 15 of them were statistically significant in patients with cirrhosis complicated by HE: infection, electrolyte disorder, hepatorenal syndrome, spontaneous peritonitis, hepatic diabetes, poor spirits, liver disease face, spider nevus, liver palm, jaundice, abdominal varicose veins, hepatomegaly, albumin, increased total bilirubin, and prothrombin time prolongation (all Ps < 0.05). The gene discussed is F2; the disease is hereditary elliptocytosis.