In addition, two different short hairpin RNA (shRNA) screening-based studies identified BRD4 and SMARCA4 as targets for acute myeloid leukemia (AML) development and maintenance, sustaining the transcription of MYC and HOXA9/MEIS, respectively, and leading to abnormal differentiation, proliferation, and survival9,10. This evidence concerns the gene MYC and acute myeloid leukemia.