For tight-control and treat-to-target treatment strategies for the treatment of RA, typically frequent disease activity assessment is applied using the Disease Activity Score (DAS), a composite score of an acute phase reactant, such as C-reactive protein (CRP), patient global assessment (PGA), and swollen and tender joint counts (SJC and TJC, respectively) of 28 or 44 joints. The gene discussed is CRP; the disease is rheumatoid arthritis.