In the lymphoid organs, mature DCs present processed exogenous peptides to naive CD4+ T-cells via MHC class II and endogenous peptides to CD8+ T-cells via MHC class I. In addition, some DCs have a superior capacity to cross-present exogenous antigens on MHC class I to CD8+ T-cells [2], which is important for the induction of cytotoxic T-cell responses against tumor cells. Here, CD8A is linked to neoplasm.