CTLA4 and melanoma: In the two ongoing trials, the mDCs are neither fully matured nor loaded with antigen ex vivo, but injected intratumorally in combination with Talimogene Laherparepvec (T-VEC; mDC-MEL-TV), an oncolytic virus approved for non-visceral melanoma metastasis [82], or the immune checkpoint inhibitors anti-CTLA4 and anti-PDL1 intratumorally and anti-PD1 intravenously (mDC-SOLID-ICI).