Previous researchers have demonstrated that COMP plays a key role in modulating liver fibrosis through activating MEK1/2 –pERK1/2 signaling and enhancing the synthesis of type 1 collagen in hepatic stellate cells (HSCs), and HSCs-derived COMP facilitates invasion and metastasis of HCC [20]. The gene discussed is MAP2K1; the disease is hepatocellular carcinoma.