Moreover, HCC-derived exosomal miR-1247-3p trans-differentiates lung fibroblasts into CAFs and then educates CAFs to secrete IL-6 and IL-8 to promote cancer stemness, chemoresistance, EMT, and tumorigenicity of HCC cells, leading to lung metastasis of HCC [9]. The gene discussed is CXCL8; the disease is hepatocellular carcinoma.