Interestingly, when rh-COMP (10 μg/mL) was administered after CMCAFs + RvD1 treatment, the expression levels of EMT-associated markers, invasive capacity, cell viability, tumor sphere formation ability and CSC-associated markers were reversed (P < 0.05, Fig. 4a-c and Additional file 9: Figure S7). This evidence concerns the gene COMP and neoplasm.