For example, peri-tumor tissue-sourced fibroblasts secrete various cytokines, including IL-6, CXCL1, CCL2, SCGF-β, CXCL8 and HGF, to recruit cancer stem cells, maintain cancer stemness and promote intrahepatic metastasis of HCC [8]. This evidence concerns the gene CXCL8 and hepatocellular carcinoma.