S1PR2 and renal artery disease: Although the exact mechanisms behind the ROCK1/Drp1 regulation by S1PR2 remind further investigation, we support the concept of S1PR2-mediated morphology and function of mitochondria of HRGECs induced by HG through the RhoA/ROCK1/Drp1 signaling pathway, suggesting that targeting this S1PR2-associated signaling pathway might be a potential therapeutic target for renal vascular disease treatment.