Germline PTEN mutations are associated with a number of tumor predisposition syndromes knowns as PTEN Hamartoma Tumors Syndromes, (PHTS) whereby affected patients develop disorganized and hyperplastic cellular overgrowths known as hamartomas that affect various tissues including thyroid, breast, skin, and brain, and can present neurodevelopmental disorders [15]. The gene discussed is PTEN; the disease is PTEN hamartoma tumor syndrome.