A recent study observed a significant increase of Beclin 1 and LC3-II along with a remarkable decrease of p62 in both IL-1β-stimulated rheumatoid arthritis fibroblast-like synoviocytes and RSC-364 cells after APS treatment, suggesting APS induces autophagy in rheumatoid arthritis. The gene discussed is BECN1; the disease is rheumatoid arthritis.