In this context, specificity and complexity of the responses are mediated by tumor cells and its microenvironment, soluble molecules such as IDO1, PD-L1 and IL-10, and cellular components such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), which limit immune cells infiltration and suppress effector T cell activity [3]. This evidence concerns the gene IL10 and neoplasm.