Among “Universal CARs”, the CD16-CR appears to offer the most reliable approach to treat solid tumors with CAR-T, for the ability to combine T cell redirection with the therapeutic activity of mAbs, for the possibility to quickly shift target antigen at the appearance of a new neoplastic phenotype, and for the possibility to utilize IgG possibly produced by B cells against tumor antigens. The gene discussed is FCGR3A; the disease is neoplasm.