The role in kidney cancer is based on the phase II HOPE 205 that randomized 153 patients progressing to the previous treatment with one VEGFR targeted agent to three different arms: Lenvatinib 24 mg/day (N = 52) versus lenvatinib plus everolimus 5 mg/day (N = 51) versus everolimus 10 mg/day (N = 50) [110] (Table 2). This evidence concerns the gene KDR and kidney cancer.