FKBP1A and fibrodysplasia ossificans progressiva: A type I receptor mutation in Fibrodysplasia Ossificans Progressiva (FOP) reduces FKBP12 binding to receptor and results in leaky BMP signaling in the absence of ligand, leading to spontaneous ossification, indicative of a potential therapeutic route for osteogenesis through targeting FKBP12 [15].