Although HP-specific intratumor T-cells, Tregs, and their communication with B-cells, or the link antigen stimulation via BCR signaling or HP CagA strain-regulated signaling, are associated with the HP-dependence of gastric MALT lymphoma [4,25,41,123,124,125], the aforementioned effects are not detected in certain proportions of HP-dependent gastric MALT lymphoma patients. The gene discussed is HP; the disease is gastric mucosa-associated lymphoid tissue lymphoma.