The signaling pathway from the CagA tyrosine phosphorylation (SHP-2, ERK, BAD, p38 MAPK (mitogen-activated protein kinase), Bcl-2, and Bcl-xL) prevents human B lymphocytes from apoptosis, allowing the lymphocytes to acquire a survival ability and develop hematological malignancies. Here, S100A8 is linked to hematologic disorder.