S100A8 and gastric cancer: In gastric cancer models, CagA passes from the HP cytosol to gastric epithelial cells using the type IV secretion system (T4SS) and further undergoes tyrosine phosphorylation by Src and abelson murine leukemia viral oncogene homolog (Abl)-family kinases on specific tyrosine residues within the EPIYA motif [83,84,85].