Taken together, the aforementioned evidences indicated the involvement of CagA in the lymphomagenesis of gastric MALT lymphoma: (1) CagA deregulates the intracellular signaling pathways in B-lymphocytes through a tyrosine phosphorylation-dependent signaling pathway to initiate the molecular pathogenesis of this tumor. This evidence concerns the gene S100A8 and gastric mucosa-associated lymphoid tissue lymphoma.