These findings indicated that HP might cause the aberrant methylation of DNA-specific genes (p16 and p57) and CpG island-specific genes (hMLH1, MINT1, MINT2, and MINT31), which are important epigenetic mechanisms contributing to the HP-dependent lymphomagenesis of gastric MALT lymphoma (Table 1). Here, MLH1 is linked to gastric mucosa-associated lymphoid tissue lymphoma.